Streptomyces sp.

By Targets:	ADC Cytotoxin (1) Antibiotic (7) Apoptosis (2) ATP Synthase (1) Bacterial (7) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fungal (3) HCV (1) Influenza Virus (1) Na+/K+ ATPase (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) Parasite (1) Phospholipase (1) Proteasome (2) SARS-CoV (1)
By Research Areas:	Cancer (8) Infection (11) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2936

*Sphingomyelin phosphodiesterase, Streptomyces* sp.**	Phospholipase	Metabolic Disease
Sphingomyelin phosphodiesterase, Streptomyces sp., a hydrolase, is involved in the sphingomyelin metabolism process. Sphingomyelin phosphodiesterase hydrolyzes the conversion of sphingomyelin to phosphocholine and ceramide. Sphingomyelin phosphodiesterase also plays an important role in cellular differentiation, various immune and inflammatory responses, and intracellular cholesterol trafficking and metabolism .

HY-125458

Iromycin A

NO Synthase Others

Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

Iromycin A	NO Synthase	Others
Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

HY-125637

Venturicidin B Aabomycin A2	Fungal ATP Synthase	Infection
Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex .

HY-N8743

Cyclo(Pro-Leu) A 65190; Cyclo-(leucyl-prolyl)	Endogenous Metabolite	Cancer
Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer .

HY-N11415

Aurachin SS	Antibiotic Bacterial	Infection
Aurachin SS is a nature product that could be isolated from Streptomyces sp. NA04227. Aurachin SS is an antibiotic and has antibacterial activity .

HY-131054

Cinerubin B

Antibiotic Bacterial Infection

Cinerubin B, a glycosylated anthracycline antibiotic, is an anticancer agent from Streptomyces sp. SPB74 .
HY-N11620

Sadopeptins A

Proteasome Others

Sadopeptins A is a nature product that could be isolated from Streptomyces sp. Sadopeptins A is a potent proteasome inhibitor .
HY-N11621

Sadopeptins B

Proteasome Others

Sadopeptins B is a nature product that could be isolated from Streptomyces sp. Sadopeptins B is a potent proteasome inhibitor .

Cinerubin B	Antibiotic Bacterial	Infection
Cinerubin B, a glycosylated anthracycline antibiotic, is an anticancer agent from Streptomyces* sp.* SPB74 .

Sadopeptins A	Proteasome	Others
Sadopeptins A is a nature product that could be isolated from Streptomyces sp. Sadopeptins A is a potent proteasome inhibitor .

Sadopeptins B	Proteasome	Others
Sadopeptins B is a nature product that could be isolated from Streptomyces sp. Sadopeptins B is a potent proteasome inhibitor .

HY-106338

Polyketomycin	Bacterial ADC Cytotoxin Parasite	Infection Cancer
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .

HY-N6738

Bafilomycin B1	Bacterial Fungal Antibiotic	Infection
Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K ⁺-dependent ATPase of E. coli .

HY-129558

UK-1	HCV	Infection Cancer
UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities . UK-1 also inhibits HCV replication .

HY-N10605

Maniwamycin E	SARS-CoV Influenza Virus	Infection
Maniwamycin E is a maniwamycin derivative isolated from the culture extract of thermotolerant Streptomyces sp. JA74. Maniwamycin E shows antiviral activity against SARS-CoV-2 and influenza (H1N1) virus .

HY-157017

Julichrome Q3.5	Biochemical Assay Reagents	Others
Julichrome Q3.5 (Compound 4) is a bioherbicide that completely inhibits the growth of cabbage. Julichrome Q3.5 can be isolated from the supernatant extract of strain Streptomyces sp. NEAU-HV44 .

HY-125747

Actinomycin X2 1 Publications Verification Actinomycin V	Bacterial Antibiotic Apoptosis	Infection Cancer
Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection .

HY-118331

Kazusamycin B PD 124895; CL-1957E	Antibiotic	Infection Cancer
Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer .

HY-163113

Anticancer agent 180	Others	Cancer
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .

HY-121071

Ascamycin	Bacterial Nucleoside Antimetabolite/Analog Antibiotic	Infection
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against *Xanthomonas* species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for *Xanthomonas citri, Xanthomonas oryzae* and *Mycobacterium phlei*, respectively .

HY-19828

Herboxidiene GEX1A	DNA/RNA Synthesis	Cancer
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .

HY-130173

Bafilomycin C1	Bacterial Fungal Na+/K+ ATPase Apoptosis Antibiotic	Infection Cancer
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H ⁺-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .

Cat. No.	Product Name	Target	Research Area

HY-125747

Actinomycin X2 1 Publications Verification Actinomycin V	Bacterial Antibiotic Apoptosis	Infection Cancer
Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125458

Iromycin A	Structural Classification Natural Products Microorganisms Source classification	NO Synthase
Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

HY-N8743

Cyclo(Pro-Leu) A 65190; Cyclo-(leucyl-prolyl)	Structural Classification Alkaloids Microorganisms Source classification	Endogenous Metabolite
Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer .

HY-N11415

Aurachin SS	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Antibiotic Bacterial
Aurachin SS is a nature product that could be isolated from Streptomyces sp. NA04227. Aurachin SS is an antibiotic and has antibacterial activity .

HY-N11620

Sadopeptins A	Structural Classification Monophenols Microorganisms Source classification Phenols	Proteasome
Sadopeptins A is a nature product that could be isolated from Streptomyces sp. Sadopeptins A is a potent proteasome inhibitor .

HY-N11621

Sadopeptins B	Structural Classification Monophenols Microorganisms Source classification Phenols	Proteasome
Sadopeptins B is a nature product that could be isolated from Streptomyces sp. Sadopeptins B is a potent proteasome inhibitor .

HY-106338

Polyketomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Naphthalene Quinones Disease Research Fields	Bacterial ADC Cytotoxin Parasite
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .

HY-N6738

Bafilomycin B1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Bacterial Fungal Antibiotic
Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K ⁺-dependent ATPase of E. coli .

HY-N10605

Maniwamycin E	Natural Products Microorganisms	SARS-CoV Influenza Virus
Maniwamycin E is a maniwamycin derivative isolated from the culture extract of thermotolerant Streptomyces sp. JA74. Maniwamycin E shows antiviral activity against SARS-CoV-2 and influenza (H1N1) virus .

HY-163113

Anticancer agent 180	Structural Classification Microorganisms Source classification Phenols	Others
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .

HY-121071

Ascamycin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Nucleoside Antimetabolite/Analog Antibiotic
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against *Xanthomonas* species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for *Xanthomonas citri, Xanthomonas oryzae* and *Mycobacterium phlei*, respectively .

HY-19828

Herboxidiene GEX1A	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	DNA/RNA Synthesis
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .

HY-130173

Bafilomycin C1	Infection Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Cancer	Bacterial Fungal Na+/K+ ATPase Apoptosis Antibiotic
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H ⁺-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .

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